Journal of Pharmacy and Pharmaceutics | Volume 6 | Issue 1 | 2019-07-20

In-vitro Quantitative and Qualitative Evaluation of the Marketed Linagliptin and Aspirin Tablets Available in Bangladesh

Md Shariful Islam

Abstract

The study was conducted with the aim to evaluate the quantitative and qualitative status of linagliptin and aspirin tablets manufactured in Bangladesh. Five and four different brand samples of linagliptin and aspirin tablets respectively were collected from retail pharmacy for spectrophotometric assay. Various physical parameters naming diameter and thickness determination, weight determination, friability, hardness, in vitro disintegration, dissolution percentage and potency were analyzed according to British Pharmacopoeia (BP) and United States Pharmacopoeia (USP). Out of total nine samples, only four samples met the BP specification of 95-105% of claimed potency. Four linagliptin and two aspirin samples complied with USP friability specification. Four samples of each generic drug met the USP specification for the in vitro disintegration and dissolution test.

Keywords: Aspirin, Linagliptin, INN drug, ICH guideline