Journal of Medicinal Chemistry and Toxicology | Volume 2 | Issue 2 | 2017-10-03

Active Targeted Nanoparticles for Anti– Cancer Nano Drugs Delivery across the Blood– Brain Barrier for Human Brain Cancer Treatment, Multiple Sclerosis (MS) and Alzheimer's Diseases Using Chemical Modifications of Anti– Cancer Nano Drugs or Drug– Nanoparticles through Zika Virus (ZIKV) Nanocarriers under Synchrotron Radiation

Alireza Heidari

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The demand for active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation has been significantly increasing in the world market due to their increased applications for various end uses [1-42] . The high crystalline nature of active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation and physically hydrophobic nature serves as barrier for easy processing. Active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation is usually treated with caustic to make them hydrophilic but they lead to decrease in strength but lipase treatment limited only to surface of active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation as the enzymes are bulky in nature they cannot penetrate into the polymeric chain of active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation and their strength is not reduced. An attempt has been made to make the fiber hydrophilic in nature. This short communication gives the process of treating active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation with ester cleaving enzyme lipase from bacterial species bacillus sp. As a result of lipase treatment, it is observed that their hydrophilic property is improved which is tested by capillary raise wicking test and drop dissipations test. The increase in the number of hydrophilic groups like COOH and OH due to the cleavage of polyethylene terephthalate ester may be the reason for improved hydrophilicity. The increase in presence of COOH and OH is confirmed by treatment of active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation with basic dye and reactive remazol dyes, respectively. There is a reduction in pilling of active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation after lipase treatment. It is founded that it may be an economical method of treatment for active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation and its blends to improve the comfort properties. Active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation is a novel immunosuppressant for using in auto-immuno diseases and transplantation. This synthetic analogue of myriocin reduces the number of blood lymphocytes by redirecting theme to the lymph node. Active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation is the first Sphingosin 1 Phosphate (S1P) receptor modulator. In Multiple Sclerosis (MS) and Alzheimer s diseases, lymphocytes that circulate in the central nervous system (e.g. the brain and spinal cord) attack myelin sheath that surrounds and protect nerve fibers (Axons). Active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation inhibits lymphocytes (T, B cells) recirculating. Clinical results after using active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation showed that fingolimode reduced the rate of relapses more than 75% and inflammatory diseases activity as measured by Magnetic Resonance Imaging (MRI) up to 85%. In this short communication, derivative of active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation such as H d Pro FTY720, Boc d Pro FTY720, H d Ala FTY720, Boc d Ala FTY72, for studies further pharmaceutical and neurological effect, were synthesized [43-50] . Over the past decade, there has been an increasing interest in using active targeted nanoparticles for anti cancer Nano drugs delivery across the blood brain barrier for human brain cancer treatment, Multiple Sclerosis (MS) and Alzheimer s diseases using chemical modifications of anti cancer Nano drugs or drug nanoparticles through Zika Virus (ZIKV) nanocarriers under synchrotron radiation for therapeutic goals in particular cancer therapy. The development of smart targeted nanoparticles (NPs) that can direct anti cancer Nano drugs at a sustained rate to human cancer stem cells may cause better efficacy and lower toxicity for treating primary and advanced metastatic tumors. Furthermore, over the past decade, a wide variety of antibody based targeting nanomolecules have been assessed for their potential application in cancer therapy. A novel class of nanomolecules, referred to as nucleic acid ligands (aptamers), has been developed that may rival antibodies in its potential for therapeutic and diagnostic applications. Aptamers are DNA or RNA oligonucleotides or modified DNA or RNA oligonucleotides that fold by intramolecular interaction into unique conformations with ligand binding characteristics. Alireza Heidari and his co workers at the BioSpectroscopy Core Research Laboratory at Faculty of Chemistry, California South University (CSU), Irvine, California, USA reported the synthesis and characterization of untrafine particles of some selected anti cancer Nano drugs by sonochemical method via controlling the synthesized condition, reaction temperature and surfactant concentration were found to be central factor in controlling production morphology and no fundamental bonding change in the anti cancer nanomolecules after preparation [51-73] . References 1. Heidari, A., Brown, C. Study of Composition and Morphology of Cadmium Oxide (CdO) Nanoparticles for Eliminating Cancer Cells. (2015) Journal of Nanomedicine Research 2(5): 20. Pubmed || Crossref || Others 2. Heidari, A., Brown, C. Study of Surface Morphological, Phytochemical and Structural Characteristics of Rhodium (III) Oxide (Rh 2 O 3 ) Nanoparticles. 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Measurement the Amount of Vitamin D2 (Ergocalciferol), Vitamin D3 (Cholecalciferol) and Absorbable Calcium (Ca 2+ ), Iron (II) (Fe 2+ ), Magnesium (Mg 2+ ), Phosphate (PO 4 ) and Zinc (Zn 2+ ) in Apricot Using High Performance Liquid Chromatography (HPLC) and Spectroscopic Techniques. (2016) J Biom Biostat 7: 292. Pubmed || Crossref || Others 19. Heidari, A. Spectroscopy and Quantum Mechanics of the Helium Dimer (He 2+ ), Neon Dimer (Ne 2+ ), Argon Dimer (Ar 2+ ), Krypton Dimer (Kr 2+ ), Xenon Dimer (Xe 2+ ), Radon Dimer(Rn 2+ ) and Ununoctium Dimer (Uuo 2+ ) Molecular Cations. (2016) J Chem Sci 7: e112. Pubmed || Crossref || Others 20. Heidari, A. Human Toxicity Photodynamic Therapy Studies on DNA/RNA Complexes as a Promising New Sensitizer for the Treatment of Malignant Tumors Using Bio Spectroscopic Techniques. (2016) J Drug Metab Toxicol (2016) 7: e129. Pubmed || Crossref || Others 21. Heidari, A. 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Molecular Dynamics and Monte Carlo Simulations for Replacement Sugars in Insulin Resistance, Obesity, LDL Cholesterol, Triglycerides, Metabolic Syndrome, Type 2 Diabetes and Cardiovascular Disease: A Glycobiological Study. (2016) J Glycobiol 5: e111. Pubmed || Crossref || Others 32. Heidari, A. Synthesis and Study of 5 (Phenylsulfonyl) Amino. 1,3,4 Thiadiazole 2 Sulfonamide as Potential Anti Pertussis Drug Using Chromatography and Spectroscopy Techniques. (2016) Transl Med (Sunnyvale) 6: e138. Pubmed || Crossref || Others 33. Heidari, A. Nitrogen, Oxygen, Phosphorus and Sulphur Heterocyclic Anti Cancer Nano Drugs Separation in the Supercritical Fluid of Ozone (O3) Using Soave Redlich Kwong (SRK) and Pang Robinson (PR) Equations. (2016) Electronic J Biol 12: 4. Pubmed || Crossref || Others 34. Heidari, A. An Analytical and Computational Infrared Spectroscopic Review of Vibrational Modes in Nucleic Acids. (2016) Austin J Anal Pharm Chem 3(1): 1058. Pubmed || Crossref || Others 35. 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Cheminformatics and System Chemistry of Cisplatin, Carboplatin, Nedaplatin, Oxaliplatin, Heptaplatin and Lobaplatin as Anti Cancer Nano Drugs: A Combined Computational and Experimental Study. (2016) J Inform Data Min 1: 3. Pubmed || Crossref || Others 43. Heidari, A. Linear and Non Linear Quantitative Structure Anti Cancer Activity Relationship (QSACAR) Study of Hydrous Ruthenium (IV) Oxide (RuO 2 ) Nanoparticles as Non Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) and Anti Cancer Nano Drugs. (2016) J Integr Oncol 5: e110. Pubmed || Crossref || Others 44. Heidari, A. Synthesis, Characterization and Biospectroscopic Studies of Cadmium Oxide (CdO) Nanoparticles Nucleic Acids Complexes Absence of Soluble Polymer as a Protective Agent Using Nucleic Acids Condensation and Solution Reduction Method. (2016) J Nanosci Curr Res 1: e101. Pubmed || Crossref || Others 45. Heidari, A. Coplanarity and Collinearity of 4 Dinonyl 2,2 Bithiazole in One Domain of Bleomycin and Pingyangmycin to be Responsible for Binding of Cadmium Oxide (CdO) Nanoparticles to DNA/RNA Bidentate Ligands as Anti Tumor Nano Drug. (2016) Int J Drug Dev & Res 8: 007 008. Pubmed || Crossref || Others 46. Heidari, A. A Pharmacovigilance Study on Linear and Non Linear Quantitative Structure (Chromatographic) Retention Relationships (QSRR) Models for the Prediction of Retention Time of Anti Cancer Nano Drugs under Synchrotron Radiations. (2016) J Pharmacovigil 4: e161. Pubmed || Crossref || Others 47. Heidari, A. Nanotechnology in Preparation of Semipermeable Polymers. (2016) J Adv Chem Eng 6: 157. Pubmed || Crossref || Others 48. Heidari, A. A Gastrointestinal Study on Linear and Non Linear Quantitative Structure (Chromatographic) Retention Relationships (QSRR) Models for Analysis 5 Aminosalicylates Nano Particles as Digestive System Nano Drugs under Synchrotron Radiations. (2016) J Gastrointest Dig Syst 6: e119. Pubmed || Crossref || Others 49. Heidari, A. DNA/RNA Fragmentation and Cytolysis in Human Cancer Cells Treated with Diphthamide Nano Particles Derivatives. (2016) Biomedical Data Mining 5: e102. Pubmed || Crossref || Others 50. Heidari, A. A Successful Strategy for the Prediction of Solubility in the Construction of Quantitative Structure Activity Relationship (QSAR) and Quantitative Structure Property Relationship (QSPR) under Synchrotron Radiations Using Genetic Function Approximation (GFA) Algorithm. (2016) J Mol Biol Biotechnol 1: 1. Pubmed || Crossref || Others 51. Heidari, A. Computational Study on Molecular Structures of C20, C60, C240, C540, C960, C2160 and C3840 Fullerene Nano Molecules under Synchrotron Radiations Using Fuzzy Logic. (2016) J Material Sci Eng 5: 282. Pubmed || Crossref || Others 52. Heidari, A. Graph Theoretical Analysis of Zigzag Polyhexamethylene Biguanide, Polyhexamethylene Adipamide, Polyhexamethylene Biguanide Gauze and Polyhexamethylene Biguanide Hydrochloride (PHMB) Boron Nitride Nanotubes (BNNTs), Amorphous Boron Nitride Nanotubes (a BNNTs) and Hexagonal Boron Nitride Nanotubes (h BNNTs). (2016) J Appl Computat Math 5: e143. Pubmed || Crossref || Others 53. Heidari, A. The Impact of High Resolution Imaging on Diagnosis. (2016) Int J Clin Med Imaging 3: 1000e101 Pubmed || Crossref || Others 54. Heidari, A. A Comparative Study of Conformational Behavior of Isotretinoin (13 Cis Retinoic Acid) and Tretinoin (All Trans Retinoic Acid (ATRA)) Nano Particles as Anti Cancer Nano Drugs under Synchrotron Radiations Using Hartree Fock (HF) and Density Functional Theory (DFT) Methods. (2016) Insights in Biomed 1: 2. Pubmed || Crossref || Others 55. Heidari, A. Advances in Logic, Operations and Computational Mathematics. (2016) J Appl Computat Math 5: 5. 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Cancer Risk Prediction and Assessment in Human Cells under Synchrotron Radiations Using Quantitative Structure Activity Relationship (QSAR) and Quantitative Structure Properties Relationship (QSPR) Studies. (2016) Int J Clin Med Imaging 3: 516. Pubmed || Crossref || Others 61. Heidari, A. A Novel Approach to Biology, Electronic. (2016) J Biol 12: 4. Pubmed || Crossref || Others 62. Heidari, A. Innovative Biomedical Equipment s for Diagnosis and Treatment. (2016) J Bioengineer & Biomedical Sci 6: 2. Pubmed || Crossref || Others 63. Heidari, A. Integrating Precision Cancer Medicine into Healthcare, Medicare Reimbursement Changes and the Practice of Oncology.Trends in Oncology Medicine and Practices. (2016) J Oncol Med & Pract 1: 2. Pubmed || Crossref || Others 64. Heidari, A. Promoting Convergence in Biomedical and Biomaterials Sciences and Silk Proteins for Biomedical and Biomaterials Applications: An Introduction to Materials in Medicine and Bioengineering Perspectives. (2016) J Bioengineer & Biomedical Sci 6: 3. Pubmed || Crossref || Others 65. Heidari, A. X Ray Fluorescence and X Ray Diffraction Analysis on Discrete Element Modeling of Nano Powder Metallurgy Processes in Optimal Container Design. (2017) J Powder Metall Min 6: 1. Pubmed || Crossref || Others 66. Heidari, A. Biomolecular Spectroscopy and Dynamics of Nano Sized Molecules and Clusters as Cross Linking Induced Anti Cancer and Immune Oncology Nano Drugs Delivery in DNA/RNA of Human Cancer Cells Membranes under Synchrotron Radiations: A Payload Based Perspective. (2017) Arch Chem Res 1: 2. Pubmed || Crossref || Others 67. Heidari, A. Deficiencies in Repair of Double Standard DNA/RNA Binding Molecules Identified in Many Types of Solid and Liquid Tumors Oncology in Human Body for Advancing Cancer Immunotherapy Using Computer Simulations and Data Analysis. (2017) J Appl Bioinforma Comput Biol 6: 1. Pubmed || Crossref || Others 68. Heidari, A. Electronic Coupling among the Five Nanomolecules Shuts Down Quantum Tunneling in the Presence and Absence of an Applied Magnetic Field for Indication of the Dimer or other Provide Different Influences on the Magnetic Behavior of Single Molecular Magnets (SMMs) as Qubits for Quantum Computing. (2017) Glob J Res Rev 4: 2. Pubmed || Crossref || Others 69. Heidari, A. Polymorphism in Nano Sized Graphene Ligand Induced Transformation of Au38 xAgx/xCux(SPh tBu)24 to Au36 xAgx/xCux(SPh tBu)24 (x = 1 12) Nanomolecules for Synthesis of Au144 xAgx/xCux(SR)60, (SC4)60, (SC6)60, (SC12)60, (PET)60, (p MBA)60, (F)60, (Cl)60, (Br)60, (I)60, (At)60, (Uus)60 and (SC6H13)60. Nano Clusters as Anti Cancer Nano Drugs. (2017) J Nanomater Mol Nanotechnol 6: 3. Pubmed || Crossref || Others 70. Heidari, A. Biomedical Resource Oncology and Data Mining to Enable Resource Discovery in Medical, Medicinal, Clinical, Pharmaceutical, Chemical and Translational Research and Their Applications in Cancer Research. 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