Journal of Nanotechnology and Materials Science | Volume 4 | Issue 2 | 2017-08-11

Design of Targeted Metal Chelation Therapeutics Nanocapsules as Colloidal Carriers and Blood-Brain Barrier (BBB) Translocation to Targeted Deliver Anti-Cancer Nano Drugs into the Human Brain to Treat Alzheimer's Disease under Synchrotron Radiation

Alireza Heidari

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HDS (Hydrodesulphurization Reaction) is a catalytic chemical process widely used to design of targeted metal chelation therapeutics nano-capsules as colloidal carriers and Blood Brain Barrier (BBB) translocation to targeted deliver anti cancer nano drugs into the human brain to treat Alzheimer s disease under synchrotron radiation [1-23] . The purpose of removing the sulphur is to design of targeted metal chelation therapeutics nano-capsules as colloidal carriers and Blood Brain Barrier (BBB) translocation to targeted deliver anti cancer nano drugs into the human brain to treat Alzheimer s disease under synchrotron radiation [24-44] . Another important reason is that sulphur, even in extremely low concentrations, poisons the novel metal catalysts (Platinum and Rhenium) in the catalytic reforming units that are subsequently used to upgrade the octane rating of the naphtha streams [45-73] . In this short communication, paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin are most used anti cancer nano drugs, which are tested for nano-medicinal and pharmaceutical applications. The anti cancer nano drugs are mostly encapsulated into the liposomes or micelles or conjugated with Polyethylene Glycol (PEG) were coated with WO3 nano-particles to design of targeted metal chelation therapeutics nano-capsules as colloidal carriers and Blood Brain Barrier (BBB) translocation to targeted deliver anti cancer nano drugs into the human brain to treat Alzheimer s disease under synchrotron radiation. The loading capacity of the W species on paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin was studied by the X Ray Diffraction (XRD) technique. The activity of as prepared paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin supported Ni W catalysts with respect to the traditional Mo based HDS (Hydrodesulphurization Reaction) catalysts were evaluated with the special set up. Results demonstrated that the paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin supported Ni W catalysts have superior activity in relation to the traditional Co Mo catalysts to design of targeted metal chelation therapeutics nano-capsules as colloidal carriers and Blood Brain Barrier (BBB) translocation to targeted deliver anti cancer nano drugs into the human brain to treat Alzheimer s disease under synchrotron radiation. Paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin which play a vital role in enzymatic processes in the mitochondria, cell nucleus and cytoplasm to design of targeted metal chelation therapeutics nano-capsules as colloidal carriers and Blood Brain Barrier (BBB) translocation to targeted deliver anti cancer nano drugs into the human brain to treat Alzheimer s disease under synchrotron radiation. In addition, paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin, with a Cobalt (III) core, serve as catalyst for oxidation of olefins. Mesoporous materials are ideal supports for immobilization and extraction of this large bio-molecule to design of targeted metal chelation therapeutics nano-capsules as colloidal carriers and Blood Brain Barrier (BBB) translocation to targeted deliver anti cancer nano drugs into the human brain to treat Alzheimer s disease under synchrotron radiation. SBA 3 mesoporous silica is synthesized by CTAB surfactant via liquid phase deposition procedure. The synthesized mesoporous silica is characterized by Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), Dynamic Light Scattering (DLS), Pulsed Laser Deposition (PLD), X Ray Diffraction (XRD) and Energy Dispersive X Ray Spectroscopy (EDX). Then, immobilization of paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin within the mesoporous silica is studied for the first time. Characterization of paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin containing mesoporous support is described using Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), Dynamic Light Scattering (DLS), Pulsed Laser Deposition (PLD), X Ray Diffraction (XRD) and Energy Dispersive X Ray Spectroscopy (EDX) and also 1 HNMR, 13 CNMR, 31 PNMR, Attenuated Total Reflectance Fourier Transform Infrared (ATR FTIR), FT Raman, UV Vis and HR Mass spectroscopies. Effect of mesoporous pore size on immobilization of this relatively large bio-molecule is taken into consideration. Results show that pore size plays a vital role on immobilization of large bio-molecule to design of targeted metal chelation therapeutics nano-capsules as colloidal carriers and Blood Brain Barrier (BBB) translocation to targeted deliver anti cancer nano drugs into the human brain to treat Alzheimer s disease under synchrotron radiation. The newly synthesized mesostructured hybrid catalyst is investigated for epoxidation of cyclo octene in presence of Hydrogen peroxide as oxidant. The ultrahigh specific area and highly dispersed catalyst species in SBA 3/paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin materials create effective and active heterogeneous catalysts for oxidation purposes in presence of hydrogen peroxide as oxidant with high conversion 89%. Vacant SBA 3 mesoporous silica is also studied for catalytic purposes to design of targeted metal chelation therapeutics nano-capsules as colloidal carriers and Blood Brain Barrier (BBB) translocation to targeted deliver anti cancer nano drugs into the human brain to treat Alzheimer s disease under synchrotron radiation. Results reveal that immobilized paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin molecules are the effective catalytic species responsible for epoxidation reaction to design of targeted metal chelation therapeutics nano-capsules as colloidal carriers and Blood Brain Barrier (BBB) translocation to targeted deliver anti cancer nano drugs into the human brain to treat Alzheimer s disease under synchrotron radiation. Paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin can be used as the electrode material in the electrochemical cells due to the subtle electronic properties to design of targeted metal chelation therapeutics nano-capsules as colloidal carriers and Blood Brain Barrier (BBB) translocation to targeted deliver anti cancer nano drugs into the human brain to treat Alzheimer s disease under synchrotron radiation. They have the ability to mediate and catalyze the electron transfer reactions with the electro-active species in a solution. Interesting investigations have been carried out concerning the electro-catalysis of paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin for dopamine, cytochrome C, azurin and cysteine to design of targeted metal chelation therapeutics nano-capsules as colloidal carriers and Blood Brain Barrier (BBB) translocation to targeted deliver anti cancer nano drugs into the human brain to treat Alzheimer s disease under synchrotron radiation. In the present short communication, paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin Nujol Paste Electrode (PE) was fabricated and characterized by Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), Dynamic Light Scattering (DLS), Pulsed Laser Deposition (PLD), X Ray Diffraction (XRD) and Energy Dispersive X Ray Spectroscopy (EDX). The resulting paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin were employed for electro-catalytic oxidation of catechol in the present of 3 methyl 1 phenyl 2 pyrazolin 5 en as a nucleophile in the aqueous solution. The electro-catalytic synthesis of 4, 5 bis (5 hydroxyl 3 methyl 1 H pyrazol 4 yl) benzene 1, 2 diol successfully was performed at paclitaxel, camptothecin, doxorubicin, cisplatin and curcumin Nujol Paste Electrode (PE). This electrode catalyzed the electro-synthesis and decreased the duration of the synthesis to a half. Following the purification, the resulting products were characterized using 1 HNMR, 13 CNMR, 31 PNMR, Attenuated Total Reflectance Fourier Transform Infrared (ATR FTIR), FT Raman, UV Vis and HR mass spectroscopies. Also, the overall yield of the synthesis and the purity of the product improved significantly. References 1. Heidari, A., Brown, C. Study of Composition and Morphology of Cadmium Oxide (CdO) Nanoparticles for Eliminating Cancer Cells. (2015) J Nanomedicine Res 2(5): 20. Pubmed | Crossref | Others 2. Heidari, A., Brown, C. Study of Surface Morphological, Phytochemical and Structural Characteristics of Rhodium (III) Oxide (Rh 2 O 3 ) Nanoparticles. (2015) International J Pharmacol, Phytochem and Ethnomedicine 1: 15-19. Pubmed | Crossref | Others 3. Heidari, A. An Experimental Biospectroscopic Study on Seminal Plasma in Determination of Semen Quality for Evaluation of Male Infertility. (2016) Int J Adv Technol 7: 007 Pubmed | Crossref | Others 4. Heidari, A. Extraction and Preconcentration of N Tolyl Sulfonyl Phosphoramid Saeure Dichlorid as an Anti Cancer Drug from Plants: A Pharmacognosy Study. (2016) J Pharmacogn Nat Prod 2: 103. Pubmed | Crossref | Others 5. Heidari, A. A Thermodynamic Study on Hydration and Dehydration of DNA and RNA Amphiphile Complexes. (2016) J Bioeng Biomed Sci S: 006. Pubmed | Crossref | Others 6. Heidari, A. Computational Studies on Molecular Structures and Carbonyl and Ketene Group s Effects of Singlet and Triplet Energies of Azidoketene O=C=CH NNN and Isocyanatoketene O=C=CH N=C=O. (2016) J Appl Computat Math 5: 142. Pubmed | Crossref | Others 7. Heidari, A. Study of Irradiations to Enhance the Induces the Dissociation of Hydrogen Bonds between Peptide Chains and Transition from Helix Structure to Random Coil Structure Using ATR FTIR, Raman and 1HNMR Spectroscopies. (2016) J Biomol Res Ther 5: 146. Pubmed | Crossref | Others 8. Heidari, A. Future Prospects of Point Fluorescence Spectroscopy, Fluorescence Imaging and Fluorescence Endoscopy in Photodynamic Therapy (PDT) for Cancer Cells. (2016) J Bioanal Biomed 8: 135. Pubmed | Crossref | Others 9. Heidari, A. Bio Spectroscopic Study of DNA Density and Color Role as Determining Factor for Absorbed. Irradiation in Cancer Cells. (2016) Adv Cancer Prev 1: 102. Pubmed | Crossref | Others 10. Heidari, A. Manufacturing Process of Solar Cells Using Cadmium Oxide (CdO) and Rhodium (III) Oxide (Rh 2 O 3 ) Nanoparticles. (2016) J Biotechnol Biomater 6: 125. Pubmed | Crossref | Others 11. Heidari, A. A Novel Experimental and Computational Approach to Photo biosimulation of Telomeric DNA/RNA: A Biospectroscopic and Photobiological Study. (2016) J Res Development 4: 144. Pubmed | Crossref | Others 12. Heidari, A. Biochemical and Pharmacodynamical Study of Microporous Molecularly Imprinted Polymer Selective for Vancomycin, Teicoplanin, Oritavancin, Telavancin and Dalbavancin Binding. (2016) Biochem Physiol 5: 146. Pubmed | Crossref | Others 13. 13. Heidari, A. Anti Cancer Effect of UV Irradiation at Presence of Cadmium Oxide (CdO) Nanoparticles on DNA of Cancer Cells: A Photodynamic Therapy Study. (2016) Arch Cancer Res 4: 1. Pubmed | Crossref | Others 14. Heidari, A. Biospectroscopic Study on Multi Component Reactions (MCRs) in Two A Type and B Type Conformations of Nucleic Acids to Determine Ligand Binding Modes, Binding Constant and Stability of Nucleic Acids in Cadmium Oxide (CdO) Nanoparticles Nucleic Acids Complexes as Anti Cancer Drugs. (2016) Arch Cancer Res 4: 2. Pubmed | Crossref | Others 15. Heidari, A. Simulation of Temperature Distribution of DNA/RNA of Human Cancer Cells Using Time Dependent Bio Heat Equation and Nd: YAG Lasers . (2016) Arch Cancer Res 4: 2. Pubmed | Crossref | Others 16. Heidari, A. Quantitative Structure Activity Relationship (QSAR) Approximation for Cadmium Oxide (CdO) and Rhodium (III) Oxide (Rh 2 O 3 ) Nanoparticles as Anti Cancer Drugs for the Catalytic Formation of Proviral DNA from Viral RNA Using Multiple Linear and Non Linear Correlation Approach. (2016) Ann Clin Lab Res 4: 1. Pubmed | Crossref | Others 17. Heidari A. Biomedical Study of Cancer Cells DNA Therapy Using Laser Irradiations at Presence of Intelligent Nanoparticles. (2016) J Biomedical Sci 5: 2. Pubmed | Crossref | Others 18. Heidari, A. Measurement the Amount of Vitamin D 2 (Ergocalciferol), Vitamin D 3 (Cholecalciferol) and Absorbable Calcium (Ca 2+ ), Iron (II) (Fe 2+ ), Magnesium (Mg 2+ ), Phosphate (PO 4 ) and Zinc (Zn 2+ ) in Apricot Using High Performance Liquid Chromatography (HPLC) and Spectroscopic Techniques. (2016) J Biom Biostat 7: 292. Pubmed | Crossref | Others 19. Heidari, A. Spectroscopy and Quantum Mechanics of the Helium Dimer (He 2+ ), Neon Dimer (Ne 2+ ), Argon Dimer (Ar 2+ ), Krypton Dimer (Kr 2+ ), Xenon Dimer (Xe 2+ ), Radon Dimer(Rn 2+ ) and Ununoctium Dimer (Uuo 2+ ) Molecular Cations. (2016) J Chem Sci 7: 112. Pubmed | Crossref | Others 20. Heidari, A. Human Toxicity Photodynamic Therapy Studies on DNA/RNA Complexes as a Promising New Sensitizer for the Treatment of Malignant Tumors Using Bio Spectroscopic Techniques. (2016) J Drug Metab Toxicol 7: 129. Pubmed | Crossref | Others 21. Heidari, A. Novel and Stable Modifications of Intelligent Cadmium Oxide (CdO) Nanoparticles as Anti Cancer Drug in Formation of Nucleic Acids Complexes for Human Cancer Cells Treatment. (2016) Biochem Pharmacol (Los Angel) 5: 207. Pubmed | Crossref | Others 22. Heidari, A. A Combined Computational and QM/MM Molecular Dynamics Study on Boron Nitride Nanotubes (BNNTs), Amorphous Boron Nitride Nanotubes (a BNNTs) and Hexagonal Boron Nitride Nanotubes (h BNNTs) as Hydrogen Storage. (2016) Struct Chem Crystallogr Commun 2: 1. Pubmed | Crossref | Others 23. Heidari, A. Pharmaceutical and Analytical Chemistry Study of Cadmium Oxide (CdO) Nanoparticles Synthesis Methods and Properties as Anti Cancer Drug and its Effect on Human Cancer Cells. (2016) Pharm Anal Chem Open Access 2: 113 Pubmed | Crossref | Others 24. Heidari, A. A Chemotherapeutic and Biospectroscopic Investigation of the Interaction of Double Standard DNA/RNA Binding Molecules with Cadmium Oxide (CdO) and Rhodium (III) Oxide (Rh 2 O 3 ) Nanoparticles as Anti Cancer Drugs for Cancer Cells Treatment. (2016) Chemo Open Access 5: 129. Pubmed | Crossref | Others 25. Heidari, A. Pharmacokinetics and Experimental Therapeutic Study of DNA and Other Biomolecules Using Lasers: Advantages and Applications. (2016) J Pharmacokinet Exp Ther 1: 005. Pubmed | Crossref | Others 26. Heidari, A. Determination of Ratio and Stability Constant of DNA/RNA in Human Cancer Cells and Cadmium Oxide (CdO) Nanoparticles Complexes Using Analytical Electrochemical and Spectroscopic Techniques. (2016) Insights Anal Electrochem 2: 1. Pubmed | Crossref | Others 27. Heidari, A. Discriminate between Antibacterial and Non Antibacterial Drugs Artificial Neutral Networks of a Multilayer Perceptron (MLP) Type Using a Set of Topological Descriptors. (2016) J Heavy Met Toxicity Dis 1: 2. Pubmed | Crossref | Others 28. Heidari, A. Combined Theoretical and Computational Study of the Belousov Zhabotinsky Chaotic Reaction and Curtius Rearrangement for Synthesis of Mechlorethamine, Cisplatin, Streptozotocin, Cyclophosphamide, Melphalan, Busulphan and BCNU as Anti Cancer Drugs. (2016) Insights Med Phys 1: 2. Pubmed | Crossref | Others 29. Heidari, A. A Translational Biomedical Approach to Structural Arrangement of Amino Acids Complexes: A Combined Theoretical and Computational Study. (2016) Transl Biomed 7: 2. Pubmed | Crossref | Others 30. Heidari, A. Ab Initio and Density Functional Theory (DFT) Studies of Dynamic NMR Shielding Tensors and Vibrational Frequencies of DNA/RNA and Cadmium Oxide (CdO) Nanoparticles Complexes in Human Cancer Cells. (2016) J Nanomedine Biotherapeutic Discov 6: 144. Pubmed | Crossref | Others 31. Heidari, A. Molecular Dynamics and Monte Carlo Simulations for Replacement Sugars in Insulin Resistance, Obesity, LDL Cholesterol, Triglycerides, Metabolic Syndrome, Type 2 Diabetes and Cardiovascular Disease: A Glycobiological Study. (2016) J Glycobiol 5: 111. Pubmed | Crossref | Others 32. Heidari, A. Synthesis and Study of 5 (Phenylsulfonyl) Amino. 1, 3, 4 Thiadiazole 2 Sulfonamide as Potential Anti Pertussis Drug Using Chromatography and Spectroscopy Techniques. (2016) Transl Med (Sunnyvale) 6: 138. Pubmed | Crossref | Others 33. Heidari, A. Nitrogen, Oxygen, Phosphorus and Sulphur Heterocyclic Anti Cancer Nano Drugs Separation in the Supercritical Fluid of Ozone (O3) Using Soave Redlich Kwong (SRK) and Pang Robinson (PR) Equations. (2016) Electronic J Biol 12: 4. Pubmed | Crossref | Others 34. Heidari, A. An Analytical and Computational Infrared Spectroscopic Review of Vibrational Modes in Nucleic Acids. (2016) Austin J Anal Pharm Chem 3(1): 1058. Pubmed | Crossref | Others 35. Heidari, A., Brown, C. Phase, Composition and Morphology Study and Analysis of Os Pd/HfC Nanocomposites. (2016) Nano Res Appl 2: 1. Pubmed | Crossref | Others 36. Heidari, A., Brown, C. Vibrational Spectroscopic Study of Intensities and Shifts of Symmetric Vibration Modes of Ozone Diluted by Cumene. (2016) International J Adv Chem 4(1): 5-9. Pubmed | Crossref | Others 37. Heidari, A. Study of the Role of Anti Cancer Molecules with Different Sizes for Decreasing Corresponding Bulk Tumor Multiple Organs or Tissues. (2016) Arch Can Res 4: 2. Pubmed | Crossref | Others 38. Heidari, A. Genomics and Proteomics Studies of Zolpidem, Necopidem, Alpidem, Saripidem, Miroprofen, Zolimidine, Olprinone and Abafungin as Anti Tumor, Peptide Antibiotics, Antiviral and Central Nervous System (CNS) Drugs. (2016) J Data Mining Genomics & Proteomics 7: 125. Pubmed | Crossref | Others 39. Heidari, A. Pharmacogenomics and Pharmacoproteomics Studies of Phosphodiesterase 5 (PDE5) Inhibitors and Paclitaxel Albumin Stabilized Nanoparticles as Sandwiched Anti Cancer Nano Drugs between Two DNA/RNA Molecules of Human Cancer Cells. (2016) J Pharmacogenomics Pharmacoproteomics 7: 153. Pubmed | Crossref | Others 40. Heidari, A. Biotranslational Medical and Biospectroscopic Studies of Cadmium Oxide (CdO) Nanoparticles DNA/RNA Straight and Cycle Chain Complexes as Potent Anti Viral, Anti Tumor and Anti Microbial Drugs: A Clinical Approach. (2016) Transl Biomed 7: 2. Pubmed | Crossref | Others 41. Heidari, A. A Comparative Study on Simultaneous Determination and Separation of Adsorbed Cadmium Oxide (CdO) Nanoparticles on DNA/RNA of Human Cancer Cells Using Biospectroscopic Techniques and Dielectrophoresis (DEP) Method. (2016) Arch Can Res 4: 2. Pubmed | Crossref | Others 42. Heidari, A. Cheminformatics and System Chemistry of Cisplatin, Carboplatin, Nedaplatin, Oxaliplatin, Heptaplatin and Lobaplatin as Anti Cancer Nano Drugs: A Combined Computational and Experimental Study. (2016) J Inform Data Min 1: 3. Pubmed | Crossref | Others 43. Heidari, A. Linear and Non Linear Quantitative Structure Anti Cancer Activity Relationship (QSACAR) Study of Hydrous Ruthenium (IV) Oxide (RuO 2 ) Nanoparticles as Non Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) and Anti Cancer Nano Drugs. (2016) J Integr Oncol 5: 110. Pubmed | Crossref | Others 44. Heidari, A. Synthesis, Characterization and Biospectroscopic Studies of Cadmium Oxide (CdO) Nanoparticles Nucleic Acids Complexes Absence of Soluble Polymer as a Protective Agent Using Nucleic Acids Condensation and Solution Reduction Method. (2016) J Nanosci Curr Res 1: 101. Pubmed | Crossref | Others 45. Heidari, A. Coplanarity and Collinearity of 4 Dinonyl 2,2 Bithiazole in One Domain of Bleomycin and Pingyangmycin to be Responsible for Binding of Cadmium Oxide (CdO) Nanoparticles to DNA/RNA Bidentate Ligands as Anti Tumor Nano Drug. (2016) Int J Drug Dev & Res 8: 007-008. Pubmed | Crossref | Others 46. Heidari, A. A Pharmacovigilance Study on Linear and Non Linear Quantitative Structure (Chromatographic) Retention Relationships (QSRR) Models for the Prediction of Retention Time of Anti Cancer Nano Drugs under Synchrotron Radiations. (2016) J Pharmacovigil 4: 161. Pubmed | Crossref | Others 47. Heidari, A. Nanotechnology in Preparation of Semipermeable Polymers. (2016) J Adv Chem Eng 6: 157. Pubmed | Crossref | Others 48. Heidari, A. A Gastrointestinal Study on Linear and Non Linear Quantitative Structure (Chromatographic) Retention Relationships (QSRR) Models for Analysis 5 Aminosalicylates Nano Particles as Digestive System Nano Drugs under Synchrotron Radiations. (2016) J Gastrointest Dig Syst 6: 119. Pubmed | Crossref | Others 49. Heidari, A. DNA/RNA Fragmentation and Cytolysis in Human Cancer Cells Treated with Diphthamide Nano Particles Derivatives. (2016) Biomedical Data Mining 5: 102. Pubmed | Crossref | Others 50. Heidari, A. A Successful Strategy for the Prediction of Solubility in the Construction of Quantitative Structure Activity Relationship (QSAR) and Quantitative Structure Property Relationship (QSPR) under Synchrotron Radiations Using Genetic Function Approximation (GFA) Algorithm. (2016) J Mol Biol Biotechnol 1: 1. Pubmed | Crossref | Others 51. Heidari, A. Computational Study on Molecular Structures of C20, C60, C240, C540, C960, C2160 and C3840 Fullerene Nano Molecules under Synchrotron Radiations Using Fuzzy Logic. (2016) J Material Sci Eng 5: 282. Pubmed | Crossref | Others 52. Heidari, A. Graph Theoretical Analysis of Zigzag Polyhexamethylene Biguanide, Polyhexamethylene Adipamide, Polyhexamethylene Biguanide Gauze and Polyhexamethylene Biguanide Hydrochloride (PHMB) Boron Nitride Nanotubes (BNNTs), Amorphous Boron Nitride Nanotubes (a BNNTs) and Hexagonal Boron Nitride Nanotubes (h BNNTs). (2016) J Appl Computat Math 5: 143. Pubmed | Crossref | Others 53. Heidari, A. The Impact of High Resolution Imaging on Diagnosis. (2016) Int J Clin Med Imaging 3: 1000e101. Pubmed | Crossref | Others 54. Heidari, A. A Comparative Study of Conformational Behavior of Isotretinoin (13 Cis Retinoic Acid) and Tretinoin (All Trans Retinoic Acid (ATRA)) Nano Particles as Anti Cancer Nano Drugs under Synchrotron Radiations Using Hartree Fock (HF) and Density Functional Theory (DFT) Methods. (2016) Insights in Biomed 1: 2. Pubmed | Crossref | Others 55. Heidari, A. Advances in Logic, Operations and Computational Mathematics. (2016) J Appl Computat Math 5: 5. Pubmed | Crossref | Others 56. Heidari, A. Mathematical Equations in Predicting Physical Behavior. (2016) J Appl Computat Math 5: 5. Pubmed | Crossref | Others 57. Heidari, A. Chemotherapy a Last Resort for Cancer Treatment. (2016) Chemo Open Access 5: 4. Pubmed | Crossref | Others 58. Heidari, A. Separation and Pre Concentration of Metal Cations DNA/RNA Chelates Using Molecular Beam Mass Spectrometry with Tunable Vacuum Ultraviolet (VUV) Synchrotron Radiation and Various Analytical Methods. (2016) Mass Spectrom Purif Tech 2: 101. Pubmed | Crossref | Others 59. Heidari, A. Yoctosecond Quantitative Structure Activity Relationship (QSAR) and Quantitative Structure Property Relationship (QSPR) under Synchrotron Radiations Studies for Prediction of Solubility of Anti Cancer Nano Drugs in Aqueous Solutions Using Genetic Function Approximation (GFA) Algorithm. (2016) Insight Pharm Res 1: 1. Pubmed | Crossref | Others 60. Heidari, A. Cancer Risk Prediction and Assessment in Human Cells under Synchrotron Radiations Using Quantitative Structure Activity Relationship (QSAR) and Quantitative Structure Properties Relationship (QSPR) Studies. (2016) Int J Clin Med Imaging 3: 516. Pubmed | Crossref | Others 61. Heidari, A. A Novel Approach to Biology, Electronic. (2016) J Biol 12: 4. Pubmed | Crossref | Others 62. Heidari, A. Innovative Biomedical Equipment s for Diagnosis and Treatment. (2016) J Bioengineer & Biomedical Sci 6: 2. Pubmed | Crossref | Others 63. Heidari, A. Integrating Precision Cancer Medicine into Healthcare, Medicare Reimbursement Changes and the Practice of Oncology. Trends in Oncology Medicine and Practices. (2016) J Oncol Med & Pract 1: 2. Pubmed | Crossref | Others 64. Heidari, A. Promoting Convergence in Biomedical and Biomaterials Sciences and Silk Proteins for Biomedical and Biomaterials Applications: An Introduction to Materials in Medicine and Bioengineering Perspectives. (2016) J Bioengineer & Biomedical Sci 6: 3. Pubmed | Crossref | Others 65. Heidari, A. X Ray Fluorescence and X Ray Diffraction Analysis on Discrete Element Modeling of Nano Powder Metallurgy Processes in Optimal Container Design. (2017) J Powder Metall Min 6: 1. Pubmed | Crossref | Others 66. Heidari, A. Biomolecular Spectroscopy and Dynamics of Nano Sized Molecules and Clusters as Cross Linking Induced Anti Cancer and Immune Oncology Nano Drugs Delivery in DNA/RNA of Human Cancer Cells Membranes under Synchrotron Radiations: A Payload Based Perspective. (2017) Arch Chem Res 1: 2. Pubmed | Crossref | Others 67. Heidari, A. Deficiencies in Repair of Double Standard DNA/RNA Binding Molecules Identified in Many Types of Solid and Liquid Tumors Oncology in Human Body for Advancing Cancer Immunotherapy Using Computer Simulations and Data Analysis. (2017) J Appl Bioinforma Comput Biol 6: 1. Pubmed | Crossref | Others 68. Heidari, A. Electronic Coupling among the Five Nanomolecules Shuts Down Quantum Tunneling in the Presence and Absence of an Applied Magnetic Field for Indication of the Dimer or other Provide Different Influences on the Magnetic Behavior of Single Molecular Magnets (SMMs) as Qubits for Quantum Computing. (2017) Glob J Res Rev 4: 2. Pubmed | Crossref | Others 69. Heidari, A. Polymorphism in Nano Sized Graphene Ligand Induced Transformation of Au38 xAgx/xCux(SPh tBu)24 to Au36 xAgx/xCux(SPh tBu)24 (x = 1 12) Nanomolecules for Synthesis of Au144 xAgx/xCux(SR)60, (SC4)60, (SC6)60, (SC12)60, (PET)60, (p MBA)60, (F)60, (Cl)60, (Br)60, (I)60, (At)60, (Uus)60 and (SC6H13)60. Nano Clusters as Anti Cancer Nano Drugs. (2017) J Nanomater Mol Nanotechnol 6: 3. Pubmed | Crossref | Others 70. Heidari, A. Biomedical Resource Oncology and Data Mining to Enable Resource Discovery in Medical, Medicinal, Clinical, Pharmaceutical, Chemical and Translational Research and Their Applications in Cancer Research. (2017) Int J Biomed Data Min 6: 103. Pubmed | Crossref | Others 71. Heidari, A. Study of Synthesis, Pharmacokinetics, Pharmacodynamics, Dosing, Stability, Safety and Efficacy of Olympiadane Nanomolecules as Agent for Cancer Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy under Synchrotorn Radiation. (2017) J Dev Drugs 6: 154. Pubmed | Crossref | Others 72. Heidari, A. A Novel Approach to Future Horizon of Top Seven Biomedical Research Topics to Watch in 2017: Alzheimer's, Ebola, Hypersomnia, Human Immunodeficiency Virus (HIV), Tuberculosis (TB), Microbiome/Antibiotic Resistance and Endovascular Stroke. (2017) J Bioengineer & Biomedical Sci 7: 127. Pubmed | Crossref | Others 73. Heidari, A. Opinion on Computational Fluid Dynamics (CFD) Technique. (2017) Fluid Mech Open Acc 4: 157. Pubmed | Crossref | Others